<3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone

Base Information

Chemical Name:<3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone
CAS No.:118832-56-7
Molecular Formula:C₁₅H₂₄O₂
Molecular Weight:236.354
Hs Code.:

Synonyms:<3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone

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Chemical Property of <3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone

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Technology Process of <3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone

There total 29 articles about <3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 118041-14-8
5(R)-bromo-6-cyclohexyl-2(S)-isopropyl-4(S)-hexanolide

: 118041-20-6
<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-azidoethyl)dihydro-3-isopropyl-2(3H)-furanone

: 118832-57-8
5-[2-Cyclohexyl-eth-(E)-ylidene]-3-isopropyl-dihydro-furan-2-one

: 118832-56-7
(3S,5S)-5-((E)-2-Cyclohexyl-vinyl)-3-isopropyl-dihydro-furan-2-one

Guidance literature:: With sodium azide; In various solvent(s); for 72h; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jo00266a034

Reference yield: 27.0%

: 118832-51-2
(2S,4S,5R)-6-cyclohexyl-5-iodo-2-(1-methylethyl)-4-hexanolide

: 118041-20-6
<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-azidoethyl)dihydro-3-isopropyl-2(3H)-furanone

: 118832-57-8
5-[2-Cyclohexyl-eth-(E)-ylidene]-3-isopropyl-dihydro-furan-2-one

: 118832-56-7
(3S,5S)-5-((E)-2-Cyclohexyl-vinyl)-3-isopropyl-dihydro-furan-2-one

Guidance literature:: With sodium azide; In various solvent(s); for 72h; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jo00266a034

Reference yield:

: 112571-70-7
Ethyl 4-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α-D-erythro-hex-2-enodialdopyranoside-(1,5)

: 118832-56-7
<3S-<3α,5β(E)>>-5-(2-cyclohexylvinylene)dihydro-3-isopropyl-2(3H)-furanone

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, reflux, 45 min, 2.) r.t., 1.5 h

2: 57 percent / Jones reagent, MgSO₄ / acetone / 0.17 h / 0 - 5 °C

3: 86 percent / hydrogen / 5 percent Pd/C / ethyl acetate / 1 h / Ambient temperature

4: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 10 min, 2.) -78 deg C, 15 min

5: 3.28 g / pyridine / 1 h / Ambient temperature

6: 1,5-diazabicyclo<4.3.0>non-5-ene / tetrahydrofuran / 0.17 h / Ambient temperature

7: 1.) CuI / 1.) Et₂O, 0 deg C, 2.) 0-5 deg C, 15 min

8: lithium bis(trimethylsilyl)amide / 0.08 h / -78 °C

9: 100 percent / 4 N aq. HCl / methanol / 0.33 h / Heating

10: 1.) triphenyl phosphine, diethyl azodicarboxylate, 2.) diphenylphosphoryl azide / 1.) THF, r.t., 5 min, 2.) r.t., 1 h

With pyridine; hydrogenchloride; copper(l) iodide; jones reagent; DBN; diphenylphosphoranyl azide; hydrogen; magnesium sulfate; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)87085-X