(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

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Chemical Name:(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole
CAS No.:1613247-34-9
Molecular Formula:C₁₇H₁₆IN₃O₄S
Molecular Weight:485.302
Hs Code.:

Synonyms:(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

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Chemical Property of (S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

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Technology Process of (S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

There total 3 articles about (S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613247-09-8
(E)-N'-(3-methyl-1-phenylbut-3-en-1-ylidene)-4-nitrobenzenesulfonohydrazide

: 1613247-34-9
(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

: (R)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Guidance literature:: With 1-iodopyrrolidin-2-one; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea; In dichloromethane; toluene; at -80 ℃; for 87h; Overall yield = 94 %; Overall yield = 22.0 mg; Inert atmosphere; Molecular sieve;
DOI:10.1021/ol5013982

Reference yield:

: 52813-35-1
3-methyl-1-phenylbut-3-en-1-one

: 1613247-34-9
(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 48 h / 20 °C / Inert atmosphere

2: 1-iodopyrrolidin-2-one; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea / dichloromethane; toluene / 87 h / -80 °C / Inert atmosphere; Molecular sieve

With 1-iodopyrrolidin-2-one; ethanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea; In dichloromethane; toluene;
DOI:10.1021/ol5013982

Reference yield:

: 2937-05-5
4-nitrobenzenesulfonohydrazide

: 1613247-34-9
(S)-5-(iodomethyl)-5-methyl-1-((4-nitrophenyl)sulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 48 h / 20 °C / Inert atmosphere

2: 1-iodopyrrolidin-2-one; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea / dichloromethane; toluene / 87 h / -80 °C / Inert atmosphere; Molecular sieve

With 1-iodopyrrolidin-2-one; ethanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea; In dichloromethane; toluene;
DOI:10.1021/ol5013982