(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

Base Information

Chemical Name:(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
CAS No.:358773-79-2
Molecular Formula:C₁₆H₁₈F₃N₃O₂
Molecular Weight:341.333
Hs Code.:

Synonyms:(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

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Chemical Property of (2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

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Technology Process of (2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

There total 3 articles about (2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 288-88-0
1,2,4-Triazole

: 850462-93-0
2-bromomethyl-2-(4-trifluoromethylphenyl)-1,3-dioxolane

: 358773-79-2
(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

Guidance literature:: 1,2,4-Triazole; With potassium hydroxide; In dimethyl sulfoxide; at 45 ℃;

2-bromomethyl-2-(4-trifluoromethylphenyl)-1,3-dioxolane; In dimethyl sulfoxide; at 140 ℃;
DOI:10.1021/jf011716w

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 358773-79-2
(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / Br₂; AlCl₃ / diethyl ether / 0 °C

2.1: 60 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

3.1: KOH / dimethylsulfoxide / 45 °C

3.2: 40 percent / dimethylsulfoxide / 140 °C

With potassium hydroxide; aluminium trichloride; bromine; toluene-4-sulfonic acid; In diethyl ether; dimethyl sulfoxide; toluene;
DOI:10.1021/jf011716w

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 358773-79-2
(2RS,4RS)-1-[4-propyl-2-(4-trifluoromethylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

2.1: KOH / dimethylsulfoxide / 45 °C

2.2: 40 percent / dimethylsulfoxide / 140 °C

With potassium hydroxide; toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;
DOI:10.1021/jf011716w