(R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide

Base Information

• Chemical Name: (R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide
• CAS No.: 935263-21-1
• Molecular Formula: C₁₁H₁₄N₂O₃S
• Molecular Weight: 254.31
• Mol file: 935263-21-1.mol

Synonyms:(R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide

Chemical Property of (R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide

There total 2 articles about (R_S,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-nitrobenzaldehdye (555-16-8) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (RS,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide (935263-21-1)

Guidance literature:

With p-toluenesulfonic acid on sillica gel; water; In neat (no solvent); for 0.5h; Sonication; Green chemistry;

DOI:10.1080/00397911.2018.1540047

Reference yield: 97.0%

4-nitrobenzyl chloride (619-73-8) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (RS,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide (935263-21-1)

Guidance literature:

With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; L-proline; In toluene; at 60 ℃; for 12h; Molecular sieve; Green chemistry;

DOI:10.1039/c6ra26490e

Reference yield: 89.0%

(RS,E)-2-methyl-N-(4-nitrobenzylidene)propane-2-sulfinamide (935263-21-1) + 1-adamantyl fluoromethyl ketone (75600-43-0) → (RS)-N-[(1R,2S)-3-((3S,5S,7S)-adamantan-1-yl)-2-fluoro-1-(4-nitrophenyl)-3-oxopropyl]-2-methylpropane-2-sulfinamide

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -70 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.6b01979

upstream raw materials:

4-nitrobenzaldehdye

(R)-2-methylpropane-2-sulfinamide

4-nitrobenzyl chloride

Downstream raw materials:

C₁₇H₂₄N₂O₃S

C₁₆H₂₄N₂O₃SSi

(R(S),2R,3R)-1-(tert-butanesulfinyl)-2-(4-nitrophenyl)-3-phenylaziridine

(R(S),2R,3R)-1-(tert-butanesulfinyl)-2-(4-nitrophenyl)-3-phenylaziridine