6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

Base Information

Chemical Name:6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine
CAS No.:1198273-72-1
Molecular Formula:C₂₀H₂₃ClF₂N₂OSi
Molecular Weight:408.951
Hs Code.:

Synonyms:6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

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Chemical Property of 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

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Technology Process of 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

There total 5 articles about 6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187820-12-7
2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

: 1198211-10-7
(3-Bromo-2,6-difluorobenzyloxy)(tert-butyl)dimethylsilane

: 1198273-72-1
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 398456-82-1
3-bromo-2,6-difluoro-benzaldehyde

: 1198273-72-1
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate / 20 °C / Cooling with ice

2: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere

With 1H-imidazole; methanol; sodium tetrahydroborate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water;

Reference yield:

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1198273-72-1
6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20 h / 20 °C

2.1: trichlorophosphate / 16 h / 105 °C

2.2: 0 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere

With caesium carbonate; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water;