(R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide

Base Information

• Chemical Name: (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide
• CAS No.: 428866-26-6
• Molecular Formula: C₂₀H₂₇NO₂
• Molecular Weight: 313.44
• Mol file: 428866-26-6.mol

Synonyms:(R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide

Chemical Property of (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide

There total 6 articles about (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-5-methyl-2-(1-butoxy-2-methyl-2-phenylpropyl)pyridine (428866-25-5) → (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide (428866-26-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetasy.2005.12.039

Reference yield:

1-[2-(5-methylpyridyl)]-2-methyl-2-phenylpropanone (428866-23-3) → (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide (428866-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: (-)-(Ipc)2BCl / 72 h / 20 °C

2: potassium hydride; 18-crown-6 / tetrahydrofuran

3: m-CPBA / CH₂Cl₂ / 20 °C

With 18-crown-6 ether; potassium hydride; 3-chloro-benzenecarboperoxoic acid; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2005.12.039

Reference yield:

1-[2-(5-methylpyridyl)]-2-methyl-2-phenylpropan-1-ol (428866-22-2) → (R)-5-methyl-1-(1-butoxy-2-methyl-2-phenylpropyl)pyridine N-oxide (428866-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / PCC on SiO₂ / CH₂Cl₂ / 20 °C

2: (-)-(Ipc)2BCl / 72 h / 20 °C

3: potassium hydride; 18-crown-6 / tetrahydrofuran

4: m-CPBA / CH₂Cl₂ / 20 °C

With 18-crown-6 ether; pyridinium chlorochromate on silica gel; potassium hydride; 3-chloro-benzenecarboperoxoic acid; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetasy.2005.12.039

upstream raw materials:

(R)-5-methyl-2-(1-butoxy-2-methyl-2-phenylpropyl)pyridine

1-[2-(5-methylpyridyl)]-2-methyl-2-phenylpropanone

1-[2-(5-methylpyridyl)]-2-methyl-2-phenylpropan-1-ol

(R)-1-[2-(5-methylpyridyl)]-2-methyl-2-phenylpropan-1-ol