N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

Base Information

Chemical Name:N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride
CAS No.:1333468-16-8
Molecular Formula:C₁₉H₂₁FN₂O₂*ClH
Molecular Weight:364.847
Hs Code.:

Synonyms:N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

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Chemical Property of N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

Chemical Property:

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Technology Process of N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

There total 5 articles about N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1333467-73-4
N-(4-(4-Fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide

: 1333468-16-8
N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1333468-16-8
N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / chloroform; water

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 120 - 125 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / dichloromethane; diethyl ether / 0.5 h / 0 °C

With hydrogenchloride; ammonia; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; dichloromethane; chloroform; water; 2: Buchwald type reaction on amides;

Reference yield:

: 179899-07-1
4-fluoro-2-methoxyphenylboronic acid

: 1333468-16-8
N-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)cyclohexanecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / Reflux; Inert atmosphere

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 120 - 125 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / dichloromethane; diethyl ether / 0.5 h / 0 °C

With hydrogenchloride; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; dichloromethane; water; 2: Buchwald type reaction on amides;