(2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Base Information

• Chemical Name: (2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat
• CAS No.: 148919-59-9
• Molecular Formula: C₂₀H₂₉NO₆
• Molecular Weight: 379.453
• Mol file: 148919-59-9.mol

Synonyms:(2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Chemical Property of (2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

There total 1 articles about (2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-Methyl 4-<2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat → (2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat (148919-59-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction; 1) CH₂Cl₂, 15 min, -65 to -60 deg C, 2) a) 5 min, -60 deg C, b) 10 min, r.t.;

DOI:10.1002/ardp.19933260208

Reference yield: 72.0%

(2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat (148919-59-9) → (2R,4S)-(+)-Methyl 4-<(R)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat (148919-57-7) + (2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat (148919-58-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 4h; Yields of byproduct given;

DOI:10.1002/ardp.19933260208

Reference yield:

(2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat (148919-59-9) → 1-<(2S,5S,6R)-2,6-Epoxy-1,4,5,6-tetrahydro-2H-3-benzoxocin-5-yl>-1-methyl-3-<(R)-1-phenylethyl>-harnstoff

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / -78 °C

2: 56 percent / p-TsOH / methanol / 2 h / Heating

3: 69 percent / LiAlH₄ / diethyl ether / 1) 10 min, -15 deg C, 2) 48 h, r.t.

4: 57 percent / ethanol / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol;

DOI:10.1002/ardp.19933260208

Downstream raw materials:

(2R,4S)-(+)-Methyl 4-<(R)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat