Technology Process of 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid
There total 3 articles about 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Tris(3,6-dioxaheptyl)amine; copper(l) chloride;
In
dimethyl sulfoxide;
at 95 ℃;
for 12h;
DOI:10.1021/jm00105a034
- Guidance literature:
-
Multi-step reaction with 3 steps
1: KOH, KCl, 27percent H2O2 / 20 °C
2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C
3: tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C
With
potassium hydroxide; sulfuric acid; Tris(3,6-dioxaheptyl)amine; potassium chloride; dihydrogen peroxide; potassium iodide; copper(l) chloride; sodium nitrite;
In
dimethyl sulfoxide;
DOI:10.1021/jm00105a034
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Na2SO4, hydroxylamine sulfate, concd. HCl / H2O
2: CH3SO3H / 70 - 80 °C
3: KOH, KCl, 27percent H2O2 / 20 °C
4: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C
5: tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C
With
hydrogenchloride; potassium hydroxide; methanesulfonic acid; sulfuric acid; Tris(3,6-dioxaheptyl)amine; potassium chloride; dihydrogen peroxide; hydroxylamine sulfate; sodium sulfate; potassium iodide; copper(l) chloride; sodium nitrite;
In
water; dimethyl sulfoxide;
DOI:10.1021/jm00105a034