ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

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Chemical Name:ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate
CAS No.:865136-33-0
Molecular Formula:C₃₂H₃₈FNO₆S
Molecular Weight:583.721
Hs Code.:

Synonyms:ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

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Chemical Property of ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

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Technology Process of ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

There total 11 articles about ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 865136-32-9
ethyl 3-(2-fluoro-4-{({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)[(2-nitrophenyl)sulfonyl]amino}phenyl)propanoate

: 865136-33-0
ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

Guidance literature:: With lithium hydroxide monohydrate; mercaptoacetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm2016123

Reference yield:

: 858096-67-0
4-({[3'-(hydroxymethyl)-2,6-dimethylbiphenyl-4-yl]oxy}methyl)tetrahydro-2H-thiopyran-4-ol

: 865136-33-0
ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 0 - 20 °C

3: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium hydroxide monohydrate; mercaptoacetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016123

Reference yield:

: 865137-77-5
ethyl 3-(4-amino-2-fluorophenyl)propanoate

: 865136-33-0
ethyl 3-{2-fluoro-4-[({4'-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 70 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 0 - 20 °C

4: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; lithium hydroxide monohydrate; mercaptoacetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016123