6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

Base Information

Chemical Name:6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate
CAS No.:960402-00-0
Molecular Formula:C₂HF₃O₂*C₂₃H₁₉ClN₂O₃S
Molecular Weight:552.958
Hs Code.:

Synonyms:6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

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Chemical Property of 6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

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Technology Process of 6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

There total 5 articles about 6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 960401-98-3
3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-2-methoxy-phenoxy}-azetidine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 960402-00-0
6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

Guidance literature:: at 20 ℃; for 1h;

Reference yield:

: 960400-33-3
3-bromo-5-(4-chloro-phenyl)-thiophene-2-carboxylic acid methyl ester

: 960402-00-0
6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

2.1: trimethylaluminum / toluene / 1 h / 20 °C

2.2: 50 °C

2.3: 1 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4.1: 1 h / 20 °C

With tetrabutyl ammonium fluoride; trimethylaluminum; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 91076-93-6
methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate

: 960402-00-0
6-[4-(azetidin-3-yloxy)-3-methoxy-phenyl]-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 4 h / 70 °C

2.1: diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

3.1: trimethylaluminum / toluene / 1 h / 20 °C

3.2: 50 °C

3.3: 1 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: 1 h / 20 °C

With tert.-butylnitrite; tetrabutyl ammonium fluoride; trimethylaluminum; diisopropylamine; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;