2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

Base Information

Chemical Name:2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine
CAS No.:706821-72-9
Molecular Formula:C₂₁H₁₉N₅O₂
Molecular Weight:373.414
Hs Code.:

Synonyms:2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

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Chemical Property of 2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

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Technology Process of 2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

There total 11 articles about 2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 706821-14-9
tert-butyl [3'-formyl-6,2'-bis(2-methoxyethoxymethoxy)-biphenyl-3-ylmethyl]-carbamate

: 3,4-diaminobenzamidine monohydrochloride

: 706821-72-9
2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

Guidance literature:: tert-butyl [3'-formyl-6,2'-bis(2-methoxyethoxymethoxy)-biphenyl-3-ylmethyl]-carbamate; 3,4-diaminobenzamidine monohydrochloride; With p-benzoquinone; In methanol; for 3h; Heating / reflux;

With hydrogenchloride; In 1,3-dioxane; methanol; for 1h;

Reference yield:

: [3'-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-bis-(2-methoxy-ethoxymethoxy)-biphenyl-3-ylmethyl]-carbamic acid tert-butyl ester

: 706821-72-9
2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.04.018

Reference yield:

: 706820-76-0
3-bromo-4-(2-methoxy-ethoxymethoxy)benzylamine

: 706821-72-9
2-(5'-aminomethyl-2,2'-dihydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran

2: Pd(PPh₃)4; aq. K₂CO₃ / toluene / Heating

3: 1,4-benzoquinone / dimethylformamide / 60 °C

4: HCl / dioxane / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.018