2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine

Base Information

• Chemical Name: 2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine
• CAS No.: 1193313-40-4
• Molecular Formula: C₂₅H₃₉N₂O₆P
• Molecular Weight: 494.568
• Mol file: 1193313-40-4.mol

Synonyms:2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine

Chemical Property of 2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine

There total 1 articles about 2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-bromo-2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]pyrimidine (1193313-38-0) + phenylboronic acid (98-80-6) → 2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine (1193313-40-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 130 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2009.08.039

Reference yield: 23.0%

2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine (1193313-40-4) → C11H9N2O6P(2-)*2Li(1+)

Guidance literature:

2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]-5-phenylpyrimidine; With trimethylsilyl bromide; In acetonitrile; at 20 ℃;

With triethylamine carbonate; In water; at 0 ℃;

In water;

DOI:10.1016/j.tet.2009.08.039

upstream raw materials:

5-bromo-2,6-di-tert-butyloxy-4-[(diisopropoxyphosphoryl)methoxy]pyrimidine

phenylboronic acid