2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

Base Information

Chemical Name:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester
CAS No.:247575-73-1
Molecular Formula:C₃₁H₃₈N₂O₃
Molecular Weight:486.654
Hs Code.:

Synonyms:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

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Chemical Property of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

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Technology Process of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

There total 3 articles about 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 146176-60-5
2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride

: 111060-52-7
(S)-2-(dibenzylamino)-3-phenylpropan-1-ol

: 247575-73-1
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

Guidance literature:: (S)-2-(dibenzylamino)-3-phenylpropan-1-ol; With sodium hydride; In tetrahydrofuran; for 1h; Heating;

2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride; In tetrahydrofuran; for 6h; Heating;
DOI:10.1055/s-1999-3575

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 247575-73-1
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; NaOH / aq. methanol / 1 h / Heating

2.1: LiAlH₄ / tetrahydrofuran / Heating

3.1: NaH / tetrahydrofuran / 1 h / Heating

3.2: 81 percent / tetrahydrofuran / 6 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; 1.1: Alkylation / 2.1: Reduction / 3.1: Metallation / 3.2: Acylation;
DOI:10.1055/s-1999-3575

Reference yield:

: 111138-83-1
N,N-dibenzyl-L-phenylalanine benzyl ester

: 247575-73-1
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiAlH₄ / tetrahydrofuran / Heating

2.1: NaH / tetrahydrofuran / 1 h / Heating

2.2: 81 percent / tetrahydrofuran / 6 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; 1.1: Reduction / 2.1: Metallation / 2.2: Acylation;
DOI:10.1055/s-1999-3575