4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde

Base Information

• Chemical Name: 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde
• CAS No.: 219685-06-0
• Molecular Formula: C₂₄H₂₀BrNO₃
• Molecular Weight: 450.332

Synonyms:4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde

Chemical Property of 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde

Chemical Property:

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Technology Process of 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde

There total 4 articles about 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-1-naphthaldehyde (7770-45-8) → 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde (219685-06-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / K₂CO₃ / acetone / 16 h / Heating

2: 78 percent / NaOH / methanol / 16 h

3: dimethylformamide / 20 °C

4: dimethylformamide / 20 °C

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm0208572

Reference yield:

4-formylnaphthalene-1-yloxyacetic acid methyl ester (219684-84-1) → 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde (219685-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / NaOH / methanol / 16 h

2: dimethylformamide / 20 °C

3: dimethylformamide / 20 °C

With sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0208572

Reference yield:

4-(4-bromo-phenyl)-1,2,3,6-tetrahydro-pyridine (91347-99-8) + 4-(2-imidazol-1-yl-2-oxo-ethoxy)-naphthalene-1-carbaldehyde → 4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalene-1-carbaldehyde (219685-06-0)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm0208572

upstream raw materials:

4-(4-bromo-phenyl)-1,2,3,6-tetrahydro-pyridine

4-formylnaphthalene-1-yloxyacetic acid

4-hydroxy-1-naphthaldehyde

4-formylnaphthalene-1-yloxyacetic acid methyl ester

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