N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine

Base Information

• Chemical Name: N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine
• CAS No.: 107450-14-6
• Molecular Formula: C₁₅H₁₁Cl₃N₄
• Molecular Weight: 353.638

Synonyms:N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine

Chemical Property of N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine

Chemical Property:

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Technology Process of N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine

There total 2 articles about N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N'-[4-(4-Chloro-phenyl)-5-cyano-3-methylsulfanyl-6-oxo-1,6-dihydro-pyridin-2-yl]-N,N-dimethyl-formamidine (107452-88-0) → N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine (107450-14-6)

Guidance literature:

With thionyl chloride; In toluene; for 2h; Heating;

DOI:10.1016/S0040-4020(01)87286-0

Reference yield:

6-Amino-4-(4-chloro-phenyl)-5-methylsulfanyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (107450-03-3) → N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine (107450-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / POCl₃ / 2 h / 65 °C

2: 73 percent / SOCl₂ / toluene / 2 h / Heating

With thionyl chloride; trichlorophosphate; In toluene;

DOI:10.1016/S0040-4020(01)87286-0

Reference yield: 100.0%

N'-[3,6-Dichloro-4-(4-chloro-phenyl)-5-cyano-pyridin-2-yl]-N,N-dimethyl-formamidine (107450-14-6) → 6-Amino-2,5-dichloro-4-(4-chloro-phenyl)-nicotinonitrile (107450-20-4)

Guidance literature:

With hydrogenchloride; for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)87286-0

upstream raw materials:

N'-[4-(4-Chloro-phenyl)-5-cyano-3-methylsulfanyl-6-oxo-1,6-dihydro-pyridin-2-yl]-N,N-dimethyl-formamidine

6-Amino-4-(4-chloro-phenyl)-5-methylsulfanyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Downstream raw materials:

6-Amino-2,5-dichloro-4-(4-chloro-phenyl)-nicotinonitrile

5-Chloro-4-(4-chloro-phenyl)-1H-pyrazolo[3,4-b]pyridine-3,6-diamine

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