S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

Base Information

Chemical Name:S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate
CAS No.:1185143-71-8
Molecular Formula:C₃₀H₃₁F₄NO₆S
Molecular Weight:609.639
Hs Code.:

S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

Synonyms:S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

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Chemical Property of S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

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Technology Process of S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

There total 4 articles about S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1185143-65-0
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole-6b-carboxylic acid

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 1185143-71-8
S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

Guidance literature:: With triethylamine; sodium iodide; In water; acetone; at 20 ℃; for 4h;

Reference yield:

: 65751-34-0
11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-6α,9α-difluoroandrosta-1,4-diene-17β-carboxylic acid

: 1185143-71-8
S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / 20 - 42 °C / Inert atmosphere

2: perchloric acid / tetrahydrofuran / 2 h / 20 °C

3: triethylamine; sodium iodide / water; acetone / 4 h / 20 °C

With formic acid; triethylamine; sodium iodide; perchloric acid; In tetrahydrofuran; water; acetone;

Reference yield:

: 6α,9α-difluoro-11β,16α,17α-trihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid

: 1185143-71-8
S-{[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-8-(2,4-difluorophenyl)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]carbonyl} dimethylthiocarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: perchloric acid / tetrahydrofuran / 2 h / 20 °C

2: triethylamine; sodium iodide / water; acetone / 4 h / 20 °C

With triethylamine; sodium iodide; perchloric acid; In tetrahydrofuran; water; acetone;