5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

Base Information

Chemical Name:5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline
CAS No.:1426449-96-8
Molecular Formula:C₁₂H₁₂FN₃O
Molecular Weight:233.245
Hs Code.:

Synonyms:5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

Chemical Property:

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Technology Process of 5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

There total 2 articles about 5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-fluorocyclopropyl)-3-(4-methyl-3-nitrophenyl)-1,2,4-oxadiazole

: 1426449-96-8
5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

: 1426449-97-9
5-(5-((1S,2R)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

Guidance literature:: With ammonium chloride; zinc; In ethanol; water; at 85 ℃; for 24h;

Reference yield:

: 1426671-13-7,74229-76-8
N'-hydroxy-4-methyl-3-nitrobenzimidamide

: 1426449-96-8
5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.05 h

1.2: 0.25 h / 120 °C / Microwave irradiation

2.1: ammonium chloride; zinc / ethanol; water / 24 h / 85 °C

With ammonium chloride; 1,1'-carbonyldiimidazole; zinc; In 1-methyl-pyrrolidin-2-one; ethanol; water;