2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile

Base Information

Chemical Name:2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile
CAS No.:1279100-75-2
Molecular Formula:C₁₄H₇F₄N
Molecular Weight:265.21
Hs Code.:

Synonyms:2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile

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Chemical Property of 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile

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Technology Process of 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile

There total 1 articles about 2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 499983-13-0
2-( 4-bromo-3-fluorophenyl)acetonitrile

: 1279100-75-2
2-(2,4'-difluorobiphenyl-4-yl)-2,2-difluoroacetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 1.03 h / -78 °C / Inert atmosphere

2.2: 3.03 h / -78 °C / Inert atmosphere

With tetrabutylammomium bromide; tert.-butyl lithium; palladium diacetate; sodium carbonate; In tetrahydrofuran; water; 1.1: Suzuki coupling;
DOI:10.1021/jm101450p