N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Base Information

Chemical Name:N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
CAS No.:1436405-54-7
Molecular Formula:C₃₇H₃₄ClN₇O₂
Molecular Weight:644.176
Hs Code.:

Synonyms:N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Suppliers and Price of N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

There total 12 articles about N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

: 1436405-51-4
5-(4-aminophenyl)-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)nicotinonitrile

: 1436405-54-7
N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: With pyridine; at 0 ℃; for 4h;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 1436405-54-7
N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 1 h / Reflux

2.1: sodium ethanolate / ethanol / 1 h / 50 °C

2.2: 1 h / 0 °C

3.1: water / dimethyl sulfoxide / 1 h / 110 °C

4.1: toluene / 6 h / Reflux

4.2: 2 h / Reflux

5.1: trichlorophosphate; lithium chloride / 3 h / Reflux

6.1: pyridine hydrochloride / 1,2-dimethoxyethane / 5 h / Reflux

7.1: hydrogenchloride; iron; ammonium chloride / water; ethanol / 1 h / 70 °C

8.1: pyridine / 4 h / 0 °C

With pyridine; hydrogenchloride; thionyl chloride; water; sodium ethanolate; pyridine hydrochloride; iron; ammonium chloride; lithium chloride; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 1436405-47-8
ethyl 2-cyano-4-(4-nitrophenyl)-3-oxobutanoate

: 1436405-54-7
N-(4-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-cyanopyridin-3-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / dimethyl sulfoxide / 1 h / 110 °C

2.1: toluene / 6 h / Reflux

2.2: 2 h / Reflux

3.1: trichlorophosphate; lithium chloride / 3 h / Reflux

4.1: pyridine hydrochloride / 1,2-dimethoxyethane / 5 h / Reflux

5.1: hydrogenchloride; iron; ammonium chloride / water; ethanol / 1 h / 70 °C

6.1: pyridine / 4 h / 0 °C

With pyridine; hydrogenchloride; water; pyridine hydrochloride; iron; ammonium chloride; lithium chloride; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2013.03.053