6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

Base Information

Chemical Name:6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol
CAS No.:1357173-38-6
Molecular Formula:C₃₁H₃₀N₂O
Molecular Weight:446.592
Hs Code.:

Synonyms:6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

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Chemical Property of 6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

Chemical Property:

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Technology Process of 6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

There total 8 articles about 6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6,7-didehydro-3-methoxy-17-phenethyl-quinolino[2',3':6,7]morphinan

: 1357173-38-6
6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

Guidance literature:: 6,7-didehydro-3-methoxy-17-phenethyl-quinolino[2',3':6,7]morphinan; With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With ammonia; water; pH=9;
DOI:10.1016/j.bmc.2011.11.047

Reference yield:

: 1069111-48-3
17-cyclopropylmethyl-8,14-dehydro-3-methoxymorphinan-6-spiro-2'-(1',3'-dioxolane)

: 1357173-38-6
6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C

2.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 4 h / Inert atmosphere; Reflux

3.1: water; potassium hydroxide / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 6 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere

5.2: pH 9

6.1: methanesulfonic acid / ethanol / 20 h / Inert atmosphere; Reflux

7.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

7.2: pH 9

With hydrogenchloride; platinum(IV) oxide; methanesulfonic acid; water; hydrogen; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; potassium hydroxide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 1,1,2,2-tetrachloroethane;
DOI:10.1016/j.bmc.2011.11.047

Reference yield:

: 1043876-55-6
C₂₃H₃₁NO₄

: 1357173-38-6
6,7-didehydro-17-phenethyl-quinolino[2',3':6,7]morphinan-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; thionyl chloride / 0 - 20 °C / Inert atmosphere

2.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C

3.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 4 h / Inert atmosphere; Reflux

4.1: water; potassium hydroxide / dimethyl sulfoxide / 3 h / 120 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 6 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere

6.2: pH 9

7.1: methanesulfonic acid / ethanol / 20 h / Inert atmosphere; Reflux

8.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

8.2: pH 9

With pyridine; hydrogenchloride; platinum(IV) oxide; thionyl chloride; methanesulfonic acid; water; hydrogen; boron tribromide; sodium tris(acetoxy)borohydride; potassium carbonate; potassium hydroxide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 1,1,2,2-tetrachloroethane;
DOI:10.1016/j.bmc.2011.11.047