ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate
CAS No.:1459129-15-7
Molecular Formula:C₂₇H₂₆O₁₀S
Molecular Weight:542.563
Hs Code.:

Synonyms:ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

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Chemical Property of ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

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Technology Process of ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

There total 4 articles about ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1459128-97-2
ethyl 2-(2-((3,4-dimethoxyphenyl)ethynyl)-5-(tosyloxy)phenoxy)acetate

: 1459129-15-7
ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

Guidance literature:: With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; magnesium sulfate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2013.07.104

Reference yield:

: 41046-68-8
4-iodobenzene-1,3-diol

: 1459129-15-7
ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 20 h / 20 °C / Reflux

1.2: 3 h / Reflux

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / Inert atmosphere; Reflux

3.1: sodium hydrogencarbonate; magnesium sulfate; sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 1 h / 20 °C

With ruthenium trichloride; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; In tetrachloromethane; water; acetone; acetonitrile; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.07.104

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1459129-15-7
ethyl 2-(2-(2-(3,4-dimethoxyphenyl)-2-oxoacetyl)-5-(tosyloxy)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 20 h / 20 °C / Reflux

1.2: 3 h / Reflux

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / Inert atmosphere; Reflux

3.1: sodium hydrogencarbonate; magnesium sulfate; sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 1 h / 20 °C

With ruthenium trichloride; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; magnesium sulfate; potassium carbonate; triethylamine; In tetrachloromethane; water; acetone; acetonitrile; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2013.07.104