(E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal

Base Information

• Chemical Name: (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal
• CAS No.: 171826-92-9
• Molecular Formula: C₁₉H₂₆O₇
• Molecular Weight: 366.411
• Mol file: 171826-92-9.mol

Synonyms:(E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal

Chemical Property of (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal

There total 7 articles about (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-formyl-2,4-dimethoxybenzoate (39503-63-4) → (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal (171826-92-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 94 percent / H₂, AcOH / 10percent Pd/C / ethyl acetate / 48 h

2: 86 percent / BF₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: K₂CO₃ / acetone / 84 h / Heating

4: 30.47 g / 4 h / 210 °C

5: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 5 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 15 min

6: 90 percent / benzene / 28 h / Heating

7: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) THF, from 0 deg C to RT, 1 h

With methanol; boron trifluoride; hydrogen; sodium hydride; potassium carbonate; ozone; acetic acid; triphenylphosphine; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetone; benzene;

DOI:10.1021/jm9501339

Reference yield:

methyl 2-hydroxy-4-methoxy-5-methylbenzoate (39503-29-2) → (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal (171826-92-9)

Guidance literature:

Multi-step reaction with 5 steps

1: K₂CO₃ / acetone / 84 h / Heating

2: 30.47 g / 4 h / 210 °C

3: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 5 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 15 min

4: 90 percent / benzene / 28 h / Heating

5: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) THF, from 0 deg C to RT, 1 h

With methanol; sodium hydride; potassium carbonate; ozone; triphenylphosphine; In acetone; benzene;

DOI:10.1021/jm9501339

Reference yield:

methyl 2,4-dimethoxy-5-methylbenzoate (93351-75-8) → (E)-2-methyl-4-<2-((methoxyethoxy)methoxy)-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl>-2-butenal (171826-92-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 86 percent / BF₃ / CH₂Cl₂ / 2 h / Ambient temperature

2: K₂CO₃ / acetone / 84 h / Heating

3: 30.47 g / 4 h / 210 °C

4: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 5 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 15 min

5: 90 percent / benzene / 28 h / Heating

6: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) THF, from 0 deg C to RT, 1 h

With methanol; boron trifluoride; sodium hydride; potassium carbonate; ozone; triphenylphosphine; In dichloromethane; acetone; benzene;

DOI:10.1021/jm9501339

upstream raw materials:

2-Methoxyethoxymethyl chloride

(E)-2-methyl-4-(2-hydroxy-1-(methoxycarbonyl)-4-methoxy-5-methyl-3-phenyl)-2-butenal

methyl 2-hydroxy-4-methoxy-5-methylbenzoate

methyl 2,4-dimethoxy-5-methylbenzoate

Downstream raw materials:

(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

(E)-methyl 4-methyl-6-<3-<1-(methoxycarbonyl)-2-((2-methoxyethoxy)methoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

(E)-methyl 3-(4-bromo-3-methyl-2-butenyl)-4-methoxy-2-((2-methoxyethoxy)methoxy)-5-methylbenzoate

2-Hydroxy-4-methoxy-3-((E)-5-methoxycarbonyl-3-methyl-pent-2-enyl)-5-methyl-benzoic acid methyl ester