(5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS No.: 129441-77-6
• Molecular Formula: C₂₃H₂₀ClNO₆S
• Molecular Weight: 473.934

Synonyms:(5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property of (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

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Technology Process of (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 3 articles about (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(6R,7S)-3-Acetoxymethyl-7-chloro-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (129460-08-8) → (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (129441-77-6) + (5S,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (129441-78-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -20 ℃; for 0.5h;

Reference yield:

3-(acetoxymethyl)-7α-chloro-Δ3-cephem-4-carboxylic acid (83759-12-0) → (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (129441-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: 14 percent / 70percent MCPBA / CH₂Cl₂ / 0.5 h / -20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

7-Aminocephalosporanic acid (957-68-6) → (5R,6R,7S)-3-Acetoxymethyl-7-chloro-5,8-dioxo-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (129441-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / 3.5 N HCl, sodium nitrite / acetone; H₂O / 1.5 h / 21 °C

2: 91 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: 14 percent / 70percent MCPBA / CH₂Cl₂ / 0.5 h / -20 °C

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In dichloromethane; water; acetone;

upstream raw materials:

(6R,7S)-3-Acetoxymethyl-7-chloro-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

3-(acetoxymethyl)-7α-chloro-Δ³-cephem-4-carboxylic acid

7-Aminocephalosporanic acid

Downstream raw materials:

3-acetoxymethyl-7α-chloro-4-spiro-<3'-(1'-cyclohexyl-4'-cyclohexylimino-2'-oxoazetidinyl)>-2-cephem 1,1-dioxide

3-acetoxymethyl-7α-chloro-4-spiro-<3'-(1'-cyclohexyl-4'-cyclohexylimino-2'-oxoazetidinyl)>-2-cephem 1α-oxide

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