(R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline

Base Information

• Chemical Name: (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline
• CAS No.: 897026-60-7
• Molecular Formula: C₂₃H₂₅ClN₂O₅
• Molecular Weight: 444.915
• Mol file: 897026-60-7.mol

Synonyms:(R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline

Chemical Property of (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline

There total 1 articles about (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.3%

(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-59-4) → (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-60-7)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol;

Reference yield: 69.0%

(R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-60-7) + 3,3-dichloro-2-propen-1-yl bromide (36469-73-5) → (R/S)-3-(3-chloro-2-methoxy-5-(3,3-dichloro-2-propen-1-yloxy)phenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ2-isoxazoline

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline