(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

Base Information

Chemical Name:(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol
CAS No.:123522-73-6
Molecular Formula:C₃₃H₄₆O₄Si
Molecular Weight:534.811
Hs Code.:

Synonyms:(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

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Chemical Property of (R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

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Technology Process of (R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

There total 12 articles about (R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53068-89-6,112898-44-9,150927-14-3,94089-47-1
(R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone

: 123522-73-6
(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 10 steps

1: p-TsOH / benzene / Heating

2: LiICA / CH₂Cl₂ / -78 °C

3: 30percent H₂O₂ aq. / CH₂Cl₂ / 0 °C

4: 1) OsO₄, NaHSO₃, 2) NaIO₄ / 1) benzene, pyridine, room temp., 2) ether, room temp.

5: NaBH₄ / ethanol / 0 °C

6: imidazole / dimethylformamide

7: p-TsOH / H₂O; tetrahydrofuran / Heating

8: 75 percent / LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / -78 °C

10: 1) n-Bu₃SnH, 2) n-BuLi / 1) AIBN / 1)80 deg C, 2) THF, -50 to -78 deg C, then 0 deg C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; n-butyllithium; dihydrogen peroxide; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; lithium diisopropyl amide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)80292-6

Reference yield:

: 123522-85-0
(2,2-Dimethyl-[1,3]dioxan-5-ylethynyl)-trimethyl-silane

: 123522-73-6
(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 2 steps

1: n-Bu₄NF / CH₂Cl₂ / Ambient temperature

2: 1) n-Bu₃SnH, 2) n-BuLi / 1) AIBN / 1)80 deg C, 2) THF, -50 to -78 deg C, then 0 deg C

With n-butyllithium; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); In dichloromethane;
DOI:10.1016/S0040-4039(01)80292-6

Reference yield:

: 123522-78-1
(R)-6-Methyl-1,4-dioxa-spiro[4.5]decane-6-carbaldehyde

: 123522-73-6
(R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / ethanol / 0 °C

2: imidazole / dimethylformamide

3: p-TsOH / H₂O; tetrahydrofuran / Heating

4: 75 percent / LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / -78 °C

6: 1) n-Bu₃SnH, 2) n-BuLi / 1) AIBN / 1)80 deg C, 2) THF, -50 to -78 deg C, then 0 deg C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80292-6