4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine
CAS No.:1350887-34-1
Molecular Formula:C₁₈H₁₆BrN₅O₄
Molecular Weight:446.26
Hs Code.:

Synonyms:4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

There total 10 articles about 4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1350887-25-0
4-amino-6-(3-bromophenyl)-5-cyano-7-(2,3,5-tri-O-benzoyl-β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

: 1350887-34-1
4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2011.10.003

Reference yield:

: 3080-30-6,6974-32-9,14215-97-5,16162-35-9,20822-87-1,21138-42-1,22249-15-6,22249-17-8,26287-72-9,53403-35-3,53403-36-4,57236-69-8,70832-64-3,99395-04-7,100101-51-7,109668-83-9,120019-54-7
1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose

: 1350887-34-1
4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 3.17 h / 20 - 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 24 h / Inert atmosphere; Reflux

3.1: sodium methylate / methanol / 12 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,O-bis-(trimethylsilyl)-acetamide; sodium methylate; potassium carbonate; In methanol; toluene; acetonitrile; 2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.003

Reference yield:

: 609-06-3
L-xylose

: 1350887-34-1
4-amino-6-(3-bromophenyl)-5-cyano-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 5 h / 20 °C

2.1: pyridine / 20 °C / Cooling with ice

3.1: sulfuric acid; acetic acid / 0 - 20 °C

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

4.2: 3.17 h / 20 - 80 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 24 h / Inert atmosphere; Reflux

6.1: sodium methylate / methanol / 12 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; sodium methylate; potassium carbonate; acetic acid; In methanol; toluene; acetonitrile; 5.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.003