4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide

Base Information

• Chemical Name: 4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide
• CAS No.: 170805-79-5
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.273
• Mol file: 170805-79-5.mol

Synonyms:4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide

Chemical Property of 4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide

There total 1 articles about 4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furfural (98-01-1) + propynoic acid benzylamide (87605-11-6) → 4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide (170805-79-5)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -20 deg C, 1 h, 2.) THF, hexane, -20 deg C, 30 min;

Reference yield:

4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide (170805-79-5) → (Z)-4-Furan-2-yl-4-hydroxy-but-2-enoic acid benzylamide (170805-92-2)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol; under 760 Torr;

Reference yield:

4-Furan-2-yl-4-hydroxy-but-2-ynoic acid benzylamide (170805-79-5) → N-Benzyl-4-furan-2-yl-4-oxo-butyramide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/CaCO₃ / ethanol / 760 Torr

2: 48 percent / toluene / 7 h / Heating

With hydrogen; Lindlar's catalyst; In ethanol; toluene;

upstream raw materials:

furfural

propynoic acid benzylamide

Downstream raw materials:

(Z)-4-Furan-2-yl-4-hydroxy-but-2-enoic acid benzylamide