dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate

Base Information

• Chemical Name: dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate
• CAS No.: 814256-31-0
• Molecular Formula: C₁₉H₂₄NO₅PS
• Molecular Weight: 409.443

Synonyms:dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate

Chemical Property of dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate

There total 4 articles about dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

dimethyl methane phosphonate (756-79-6) + (SS,3R)-(+)-3-[N-(p-toluenesulfinyl)amino]-N-methoxy-N-methyl-3-(phenyl)propionamide (507453-94-3) → dimethyl (SS,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate (814256-31-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 3h;

DOI:10.1021/jo0402780

Reference yield: 84.0%

(SS,3R)-(+)-methyl 3-[N-(p-toluenesulfinyl)amino]-3-(phenyl)propanoate (158009-86-0) + dimethyl methane phosphonate (756-79-6) → dimethyl (SS,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate (814256-31-0)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.25h;

(S_S,3R)-(+)-methyl 3-[N-(p-toluenesulfinyl)amino]-3-(phenyl)propanoate; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2h;

DOI:10.1021/ol048157+

Reference yield:

(S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → dimethyl (SS,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate (814256-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KHMDS / toluene; diethyl ether / 2 h / -78 °C

2: 88 percent / n-BuLi / tetrahydrofuran; cyclohexane / 3 h / -78 °C

With n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; cyclohexane; toluene;

DOI:10.1021/jo0402780

upstream raw materials:

(S_S,3R)-(+)-methyl 3-[N-(p-toluenesulfinyl)amino]-3-(phenyl)propanoate

dimethyl methane phosphonate

(S_S,3R)-(+)-3-[N-(p-toluenesulfinyl)amino]-N-methoxy-N-methyl-3-(phenyl)propionamide

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

Downstream raw materials:

(4-oxo-6-phenyl-1,4,5,6-tetrahydro-pyridin-3-yl)-phosphonic acid dimethyl ester

(2S,6R)-(+)-benzyl 2-propyl-6-phenyl-5,6-dihydropyridine-1-carboxylate

(2S,6R)-(+)-benzyl 2-propyl-6-phenylpiperidine-1-carboxylate

(R)-(-)-benzyl-5-(dimethoxyphosphoryl)-4-oxo-2-phenyl-3,4-dihydropyridine-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 814256-31-0 dimethyl (S_S,R)-(+)-2-oxo-4-(p-toluenesulfinylamino)-4-phenyl-butylphosphonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send