1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

Base Information

Chemical Name:1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol
CAS No.:1089209-87-9
Molecular Formula:C₂₅H₂₉F₃N₂O₅S
Molecular Weight:526.577
Hs Code.:

Synonyms:1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

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Chemical Property of 1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

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Technology Process of 1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

There total 5 articles about 1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.8%

: 65040-68-8
4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

: 1089210-25-2
2,3-dihydro-2,2-dimethyl-7-(oxiranyl-methoxy)-benzofuran-5-sulfonamide

: 1089209-87-9
1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

Guidance literature:: With sodium carbonate; at 160 ℃; for 7h;

Reference yield:

: 1089210-09-2
7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride

: 1089209-87-9
1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / acetonitrile / 2 h / 5 - 10 °C / Cooling with acetone-dry ice

1.2: 2 h / Heating / reflux

2.1: sodium hydroxide / water / 0.08 h / 5 °C

2.2: 4.75 h / 5 - 40 °C

3.1: sodium carbonate / 7 h / 160 °C

With sodium hydroxide; ammonia; sodium carbonate; In water; acetonitrile;

Reference yield:

: 1089210-10-5
2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofuran-5-sulfonic acid amide

: 1089209-87-9
1-[(5-sulfamoyl-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.08 h / 5 °C

1.2: 4.75 h / 5 - 40 °C

2.1: sodium carbonate / 7 h / 160 °C

With sodium hydroxide; sodium carbonate; In water;