N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester

Base Information

• Chemical Name: N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester
• CAS No.: 159322-60-8
• Molecular Formula: C₃₉H₃₆F₅N₃O₇
• Molecular Weight: 753.723

Synonyms:N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester

Chemical Property of N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester

Chemical Property:

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Technology Process of N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester

There total 3 articles about N^ε-<2-(tert-butoxycarbonylamino)benzoyl>-N^α-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + (S)-6-(2-tert-Butoxycarbonylamino-benzoylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (159322-59-5) → Nε-<2-(tert-butoxycarbonylamino)benzoyl>-Nα-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester (159322-60-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → Nε-<2-(tert-butoxycarbonylamino)benzoyl>-Nα-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester (159322-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, 2.) N-ethylmorpholine / 2) DMF, room temperature, 1 h

2: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C

With N-ethylmorpholine;; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;

Reference yield:

3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl 2-(tert-butoxycarbonylamino)benzoate → Nε-<2-(tert-butoxycarbonylamino)benzoyl>-Nα-(fluoren-9-ylmethoxycarbonyl)-L-lysine pentafluorophenyl ester (159322-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, 2.) N-ethylmorpholine / 2) DMF, room temperature, 1 h

2: 79 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C

With N-ethylmorpholine;; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;

upstream raw materials:

2,3,4,5,6-pentafluorophenol

(S)-6-(2-tert-Butoxycarbonylamino-benzoylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid

Fmoc-Lys(tert-butoxycarbonyl)

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