1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Name:1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:202127-41-1
Molecular Formula:C₃₈H₄₇N₃O₆Si
Molecular Weight:669.893
Hs Code.:

1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 4 articles about 1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 202127-39-7
1-{2-[(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-pyrrolidin-1-yl]-2-oxo-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

: 14470-28-1
mono-4-methoxytrityl chloride

: 202127-41-1
1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; at 40 - 50 ℃;
DOI:10.1002/chem.19970031215

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 202127-41-1
1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) benzotriazol-1-yl-N-tetramethyluronium hexafluorophosphate, HOBt, N-methylmorpholine / 1.) DMF, pyridine, 5 min., 2.) DMF, pyridine, 2 h, room temperature

2: 68 percent / imidazole / dimethylformamide / 48 h

3: 75 percent / pyridine / 40 - 50 °C

With 4-methyl-morpholine; pyridine; 1H-imidazole; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/chem.19970031215

Reference yield:

: 104587-51-1
(2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine

: 202127-41-1
1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) benzotriazol-1-yl-N-tetramethyluronium hexafluorophosphate, HOBt, N-methylmorpholine / 1.) DMF, pyridine, 5 min., 2.) DMF, pyridine, 2 h, room temperature

2: 68 percent / imidazole / dimethylformamide / 48 h

3: 75 percent / pyridine / 40 - 50 °C

With 4-methyl-morpholine; pyridine; 1H-imidazole; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/chem.19970031215