(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

Base Information

Chemical Name:(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone
CAS No.:117498-69-8
Molecular Formula:C₁₂H₁₂N₂OS
Molecular Weight:232.306
Hs Code.:

Synonyms:(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

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Chemical Property of (3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

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Technology Process of (3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

There total 7 articles about (3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117498-68-7
(4-Amino-3-methyl-5-nitro-phenyl)-thiophen-2-yl-methanone

: 117498-69-8
(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 2h;
DOI:10.1021/jm00122a020

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 117498-69-8
(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / AlCl₃ / CH₂Cl₂ / 0.75 h / < 12 deg C

2: 95 percent / BBr₃ / CH₂Cl₂ / a) ice cooling, 30 min, b) room temperature, 5 h

3: 96 percent / conc. sulfuric acid, conc. nitric acid / 2 h / ice cooling

4: 47 percent / K₂CO₃ / acetone / 12 h / Heating

5: 98 percent / ammonia (g) / dimethylsulfoxide / 3 h / 85 °C

6: H₂ / 10percent Pd/C / methanol / 2 h / 50 °C

With aluminium trichloride; sulfuric acid; ammonia; hydrogen; nitric acid; boron tribromide; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00122a020

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 117498-69-8
(3,4-Diamino-5-methyl-phenyl)-thiophen-2-yl-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / CHCl₃ / Heating

2: 99 percent / AlCl₃ / CH₂Cl₂ / 0.75 h / < 12 deg C

3: 95 percent / BBr₃ / CH₂Cl₂ / a) ice cooling, 30 min, b) room temperature, 5 h

4: 96 percent / conc. sulfuric acid, conc. nitric acid / 2 h / ice cooling

5: 47 percent / K₂CO₃ / acetone / 12 h / Heating

6: 98 percent / ammonia (g) / dimethylsulfoxide / 3 h / 85 °C

7: H₂ / 10percent Pd/C / methanol / 2 h / 50 °C

With aluminium trichloride; thionyl chloride; sulfuric acid; ammonia; hydrogen; nitric acid; boron tribromide; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; chloroform; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00122a020