(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Base Information

Chemical Name:(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester
CAS No.:784208-93-1
Molecular Formula:C₁₆H₁₉I₂NO₆
Molecular Weight:575.139
Hs Code.:

(S)-N<sup>α</sup>-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Synonyms:(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

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Chemical Property of (S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Chemical Property:

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Technology Process of (S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

There total 5 articles about (S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 784208-92-0
(S)-N^α-(tert-butyloxycarbonyl)-4-hydroxy-3,5-diiodophenylglycine methyl ester

: 108-24-7
acetic anhydride

: 784208-93-1
(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Guidance literature:: With potassium carbonate; In acetone; for 2h;
DOI:10.1039/b408820d

Reference yield:

: (S)-α-amino-α(4-hydroxyphenyl)acetic acid hydrochloride

: 784208-93-1
(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 4 h / Heating

2: 7.39 g / Et₃N; water / dioxane / 5 h / pH 8.5

3: 80 percent / N-iodosuccinimide / acetone

4: 97 percent / K₂CO₃ / acetone / 2 h

With N-iodo-succinimide; thionyl chloride; water; potassium carbonate; triethylamine; In 1,4-dioxane; acetone;
DOI:10.1039/b408820d

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 784208-93-1
(S)-N^α-(tert-butyloxycarbonyl)-4-acetoxy-3,5-diiodophenylglycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.39 g / Et₃N; water / dioxane / 5 h / pH 8.5

2: 80 percent / N-iodosuccinimide / acetone

3: 97 percent / K₂CO₃ / acetone / 2 h

With N-iodo-succinimide; water; potassium carbonate; triethylamine; In 1,4-dioxane; acetone;
DOI:10.1039/b408820d