(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

Base Information

Chemical Name:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate
CAS No.:1383006-39-0
Molecular Formula:C₂HF₃O₂*C₂₂H₂₁N₃O₅
Molecular Weight:521.45
Hs Code.:

Synonyms:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

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Chemical Property of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

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Technology Process of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

There total 9 articles about (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383006-34-5
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1383006-39-0
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

Guidance literature:: (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid ethyl ester trifluoroacetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

With acetic acid; In tetrahydrofuran;

trifluoroacetic acid;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383006-39-0
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -65 °C / Inert atmosphere

4.2: 2 h / -35 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 2.25 h / 0 °C

6.1: potassium carbonate / 20 h / 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol / 3 h / 25 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

9.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With dmap; lithium hydroxide monohydrate; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1383026-42-3
[(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester

: 1383006-39-0
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-[(2-hydroxypyrimidine-5-carbonyl)amino]pentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 3 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

4.2: 0.5 h

5.1: hydrogenchloride / water / 20 h / 90 - 95 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; lithium hydroxide monohydrate; water; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; hexanes; water; ethyl acetate; N,N-dimethyl-formamide; toluene;