Technology Process of 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-2-propynol
There total 3 articles about 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-2-propynol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-ethynylveratrole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.96667h;
Schlenk technique;
Inert atmosphere;
salicylaldehyde;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 4.03333h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/adsc.201700993
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 24 h / 90 °C / Inert atmosphere
2.1: potassium hydroxide / toluene / 22 h / 110 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1.97 h / -78 °C / Schlenk technique; Inert atmosphere
3.2: 4.03 h / -78 °C / Schlenk technique; Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; triethylamine; potassium hydroxide;
In
tetrahydrofuran; hexane; toluene;
1.1: |Sonogashira Cross-Coupling;
DOI:10.1002/adsc.201700993
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide / toluene / 22 h / 110 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.97 h / -78 °C / Schlenk technique; Inert atmosphere
2.2: 4.03 h / -78 °C / Schlenk technique; Inert atmosphere
With
n-butyllithium; potassium hydroxide;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1002/adsc.201700993
