(R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester

Base Information

• Chemical Name: (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester
• CAS No.: 188194-85-6
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.341
• Mol file: 188194-85-6.mol

Synonyms:(R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester

Chemical Property of (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester

There total 1 articles about (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-allylglycine (54594-06-8) → (R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester (188194-85-6)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 3 h / 60 °C

2: LiI, NaHCO₃ / acetonitrile / 17 h / Heating

3: Et₃N, DMAP / CH₂Cl₂ / 6 h / Heating

With dmap; thionyl chloride; sodium hydrogencarbonate; triethylamine; lithium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(96)02390-8

Reference yield: 93.0%

(R)-2-(Allyl-tert-butoxycarbonyl-amino)-pent-4-enoic acid methyl ester (188194-85-6) → methyl (R)-1-tert-butoxycarbonyl-3,6-dihydro-2H-pyridine-2-carboxylate (164298-41-3)

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; for 0.5h; Heating;

DOI:10.1016/S0040-4039(96)02390-8

upstream raw materials:

D-allylglycine

Downstream raw materials:

methyl (R)-1-tert-butoxycarbonyl-3,6-dihydro-2H-pyridine-2-carboxylate