4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Name:4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:126922-84-7
Molecular Formula:C₄₀H₃₅ClN₆O₆S₂
Molecular Weight:795.34
Hs Code.:

4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Synonyms:4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of 4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of 4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 3 articles about 4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: C₂₄H₂₀N₄O₃S

: para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

: 126922-84-7
4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/acsinfecdis.0c00070

Reference yield:

: [(Z)-Methoxyimino]-[5-(trityl-amino)-[1,2,4]thiadiazol-3-yl]-acetic acid

: 126922-84-7
4-methoxybenzyl-(Z)-3-(chloromethyl)-7-(2-(methoxyimino)-2-(5-(tritylamino)-1,2,4-thiadiazol-3-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: i-Pr₂NEt / CH₂Cl₂ / Heating

2: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.7164/antibiotics.48.417