(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Base Information

Chemical Name:(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid
CAS No.:404867-98-7
Molecular Formula:C₆₀H₈₀O₉Si
Molecular Weight:973.375
Hs Code.:

Synonyms:(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Suppliers and Price of (R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

There total 11 articles about (R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-02-5,81031-90-5
pentadecanolide

: 404867-98-7
(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: hexane; tetrahydrofuran / 2 h / -40 °C

1.3: 3.1 g / H₂; [RuCl₂(COD)]n; Et₃N / (R)-BINAP / methanol; tetrahydrofuran / 15 h / 70 °C / 11400 Torr

2.1: 81 percent / imidazole / dimethylformamide / 4 h / 20 °C

3.1: 62 percent / 4A molecular sieves; BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 °C

4.1: F₃CCO₂H / CH₂Cl₂ / 3 h / 0 - 20 °C

5.1: 585 mg / NH₃ / methanol

With 1H-imidazole; 4 A molecular sieve; boron trifluoride diethyl etherate; ammonia; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja036521e

Reference yield:

: 404867-95-4
17-hydroxy-3-oxo-heptadecanoic acid tert-butyl ester

: 404867-98-7
(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / H₂ / [(R)-BINAP*RuCl₂]2*NEt₃ / methanol; tetrahydrofuran / 15 h / 70 °C / 11400.8 Torr

2: 81 percent / imidazole / dimethylformamide / 4 h / 20 °C

3: molecular sieves 4 Angstroem; BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 °C

4: CF₃COOH / CH₂Cl₂ / 0 - 20 °C

5: 585 mg / NH₃ / methanol

With 1H-imidazole; 4 A molecular sieve; boron trifluoride diethyl etherate; ammonia; hydrogen; trifluoroacetic acid; [(R)-BINAP RuCl₂]2NEt₃; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0175791

Reference yield:

: 4356-77-8,35094-65-6,61277-56-3,65556-30-1,78185-13-4,78185-15-6,109958-31-8,109958-33-0,113532-02-8,59433-13-5
1,6-di-O-acetyl-2,3,4-tri-O-benzyl-D-glucopyranose

: 404867-98-7
(R)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 13.5 g / H₂NNH₂*AcOH / dimethylformamide / 5 h / 20 °C

2: 74 percent / NaH / CH₂Cl₂ / 2 h

3: 62 percent / 4A molecular sieves; BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 °C

4: F₃CCO₂H / CH₂Cl₂ / 3 h / 0 - 20 °C

5: 585 mg / NH₃ / methanol

With 4 A molecular sieve; boron trifluoride diethyl etherate; ammonia; hydrazinium monoacetate; sodium hydride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja036521e