1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine

Base Information

• Chemical Name: 1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine
• CAS No.: 117132-44-2
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.314
• European Community (EC) Number: 673-503-1
• DSSTox Substance ID: DTXSID20366135
• Wikidata: Q82151234
• ChEMBL ID: CHEMBL4528143
• Mol file: 117132-44-2.mol

Synonyms:117132-44-2;1-[2-(4-methoxyphenoxy)ethyl]piperazine;1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine;1-(2-(4-methoxyphenoxy)ethyl)piperazine;MFCD03231419;CHEMBL4528143;SCHEMBL19462908;DTXSID20366135;BBL029922;STL244079;AKOS000322088;VS-09505;1-[2-(4-Methoxyphenoxy)-ethyl]piperazine;BB 0217766;CS-0116575;FT-0677768;EN300-11762;SR-01000062516;J-003510;SR-01000062516-1;Z57990008

Chemical Property of 1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 236.152477885
• Heavy Atom Count: 17
• Complexity: 200

Purity/Quality:

98%Min ^*data from raw suppliers

1-[2-(4-Methoxyphenoxy)ethyl]piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OCCN2CCNCC2

Technology Process of 1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine

There total 5 articles about 1-[2-(4-Methoxy-phenoxy)-ethyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 4-(2-(4-methoxyphenoxy)ethyl)piperazine-1-carboxylate → 1-(2-(4-methoxyphenoxy)ethyl)piperazine (117132-44-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

piperazine (110-85-0) + 1-(2-bromoethoxy)-4-methoxybenzene (22921-76-2) → 1-(2-(4-methoxyphenoxy)ethyl)piperazine (117132-44-2)

Guidance literature:

With hydrogen bromide; In ethanol; water; at 20 ℃; for 48h; Reflux;

DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

1-(2-bromoethoxy)-4-methoxybenzene (22921-76-2) → 1-(2-(4-methoxyphenoxy)ethyl)piperazine (117132-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / butan-1-ol

2: aq. KOH

With potassium hydroxide; potassium carbonate; In butan-1-ol;

upstream raw materials:

1-(2-bromoethoxy)-4-methoxybenzene

piperazine

4-methoxy-phenol

Downstream raw materials:

thiophen-2-yl(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone

N-(thiazol-2-yl)-2-(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)acetamide

(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone

Refernces

• 1、 -. "SELECTIVE D3 DOPAMINE RECEPTOR AGONISTS AND METHODS OF THEIR USE". . . Retrieved 2017/11/16.
• 2、 Marona,Korona,Szneler. "Synthesis and anticonvulsant activity of some piperazine derivatives.". . p. 329 - 335. Retrieved 2007/10/03.