Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

Base Information

Chemical Name:Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate
CAS No.:1310698-05-5
Molecular Formula:C₃₃H₄₆N₆O₄
Molecular Weight:590.766
Hs Code.:

Synonyms:Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

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Chemical Property of Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

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Technology Process of Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

There total 4 articles about Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 947928-12-3
(3-formylphenoxy)acetic acid isopropyl ester

: 1310698-07-7
N₁-{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}N₂,N₂-dimethylethane-1,2-diamine

: 1310698-05-5
Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 120h;

Reference yield:

: 1310698-06-6
N-{4-[4-Amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-N-[2-(dimethylamino)ethyl]-2-nitrobenzenesulfonamide

: 1310698-05-5
Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 20 °C

2: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 120 h / 20 °C

With sodium cyanoborohydride; acetic acid; mercaptoacetic acid; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 313350-42-4
4-(4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl)butaneamine

: 1310698-05-5
Isopropyl 2-{3-[({4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}{2-[dimethylamino]ethyl}amino)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane; tetrahydrofuran / 2 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 50 °C

3: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 20 °C

4: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 120 h / 20 °C

With di-isopropyl azodicarboxylate; sodium cyanoborohydride; acetic acid; mercaptoacetic acid; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;