di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate
CAS No.:1532519-05-3
Molecular Formula:C₃₀H₄₂N₄O₇
Molecular Weight:570.686
Hs Code.:

Synonyms:di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Chemical Property of di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

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Technology Process of di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

There total 7 articles about di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₅NO₁₀S

: 1532519-05-3
di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With sodium azide; sodium iodide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1h;
DOI:10.1021/ol403434e

Reference yield:

: 1532518-97-0
C₂₂H₃₃NO₅

: 1532519-05-3
di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: potassium tert-butylate; tert-butyl alcohol / benzene / 1 h / 0 - 20 °C

3: iodine; silver nitrate / acetonitrile / 2 h / 20 - 60 °C

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 1 h / 20 °C / Sonication

5: triethylamine / dichloromethane / 2 h / 0 °C

6: sodium azide; sodium iodide / N,N-dimethyl-formamide / 1 h / 20 - 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; potassium tert-butylate; iodine; silver nitrate; triethylamine; sodium iodide; tert-butyl alcohol; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene; 4: |Sonogashira Cross-Coupling;
DOI:10.1021/ol403434e

Reference yield:

: 1532518-99-2
di-tert-butyl (2S,3S,4S)-3-(2-(tert-butoxy)-2-oxoethyl)-4-(2-methoxyphenyl)pyrrolidine-1,2-dicarboxylate

: 1532519-05-3
di-tert-butyl (2S,3S,4S)-4-(5-(3-azidoprop-1-yn-1-yl)-2-methoxyphenyl)-3-(2-(tert-butoxy)-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver nitrate / acetonitrile / 2 h / 20 - 60 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 1 h / 20 °C / Sonication

3: triethylamine / dichloromethane / 2 h / 0 °C

4: sodium azide; sodium iodide / N,N-dimethyl-formamide / 1 h / 20 - 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; iodine; silver nitrate; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol403434e