cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

Base Information

Chemical Name:cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide
CAS No.:1204483-29-3
Molecular Formula:C₂₂H₂₈N₂O₃
Molecular Weight:368.476
Hs Code.:

Synonyms:cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

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Chemical Property of cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

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Technology Process of cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

There total 7 articles about cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1204484-07-0
3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine trifluoroacetate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1204483-29-3
cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield: 62.0%

: 1204484-06-9
3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1204483-29-3
cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm101179e

Reference yield:

: 1257243-84-7
5-(4-bromophenoxy)-2-chloropyridine

: 1204483-29-3
cyclopropanecarboxylic acid {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 1 h / 20 °C / Cooling

1.2: 3 h / 85 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C

3.1: 10% palladium on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 2250.23 Torr

4.1: hydrazine hydrate / ethanol / 2 h / Reflux

5.1: triethylamine / dichloromethane / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 2.1: Sonogashira coupling;
DOI:10.1021/jm101179e