(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Base Information

Chemical Name:(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol
CAS No.:124498-90-4
Molecular Formula:C₂₆H₃₀N₆O₄
Molecular Weight:490.562
Hs Code.:

Synonyms:(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

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Chemical Property of (2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

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Technology Process of (2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

There total 6 articles about (2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 124499-29-2
2-<4-(2-phenylethyl)phenyl>ethylamine

: 146-77-0
2-Chloroadenosine

: 124498-90-4
(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: at 140 ℃; for 4h;
DOI:10.1021/jm00112a035

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 124498-90-4
(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / palladium acetate, tri-o-tolylphosphine, triethylamine / 18 h / Heating

2: 97 percent / hydrazine hydrate / ethanol / 18 h / Heating

3: 91 percent / H₂, 1 N HCl / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr

4: 29 percent / 4 h / 140 °C

With hydrogenchloride; hydrogen; palladium diacetate; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00112a035

Reference yield:

: 73918-56-6
4-Bromophenethylamine

: 124498-90-4
(2R,3R,4S,5R)-2-{6-Amino-2-[2-(4-phenethyl-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / acetic acid / 18 h / Heating

2: 86 percent / palladium acetate, tri-o-tolylphosphine, triethylamine / 18 h / Heating

3: 97 percent / hydrazine hydrate / ethanol / 18 h / Heating

4: 91 percent / H₂, 1 N HCl / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr

5: 29 percent / 4 h / 140 °C

With hydrogenchloride; hydrogen; palladium diacetate; hydrazine hydrate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00112a035