2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide

Base Information

• Chemical Name: 2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide
• CAS No.: 1220525-01-8
• Molecular Formula: C₂₀H₁₅ClFN₅OS
• Molecular Weight: 427.889

Synonyms:2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide

Chemical Property of 2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide

Chemical Property:

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Technology Process of 2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide

There total 1 articles about 2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid ethyl ester (1220524-97-9) → 2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide (1220525-01-8)

Guidance literature:

With hydrazine hydrate; In ethanol; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2009.12.042

Reference yield: 78.0%

2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide (1220525-01-8) + Benzoyl isothiocyanate (532-55-8) → N-(N'-{2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carbonyl}hydrazinocarbothionyl)benzamide (1220525-05-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.12.042

Reference yield: 65.0%

2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid hydrazide (1220525-01-8) + 4-(trifluoromethyl)benzoyl isocyanate (125931-36-4) → N-(N'-{2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methyl-thiazole-5-carbonyl}hydrazinocarbonyl)-4-(trifluoromethyl)benzamide (1220525-07-4)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2009.12.042

upstream raw materials:

2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carboxylic acid ethyl ester

Downstream raw materials:

N-(N'-{2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methyl-thiazole-5-carbonyl}hydrazinocarbonyl)-4-(trifluoromethyl)benzamide

C₂₄H₂₀ClFN₆O₂S

N-(N'-{2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazole-5-carbonyl}hydrazinocarbothionyl)benzamide

5-{2-[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-4-methylthiazol-5-yl}-3H-[1,3,4]oxadiazol-2-one

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