(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

Base Information

Chemical Name:(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt
CAS No.:1361416-06-9
Molecular Formula:C₂H₆O₃S*C₁₉H₁₆FN₅O
Molecular Weight:459.501
Hs Code.:

Synonyms:(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

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Chemical Property of (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

Chemical Property:

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Technology Process of (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

There total 4 articles about (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 594-45-6
ethanesulfonic acid

: 1361415-84-0
(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

: 1361416-06-9
(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

Guidance literature:: In ethanol; Reflux;

Reference yield:

: 1241914-72-6
(4-chloroquinazoline-2-yl)(4-fluorophenyl)methanone

: 1361416-06-9
(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 40 °C

2: hydrogen / isopropyl alcohol; water; dimethyl sulfoxide / 18 h / 40 °C / 22496.5 Torr

3: ethanol / Reflux

With hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 34632-69-4
ethyl 4-chloro-quinazoline-2-carboxylate

: 1361416-06-9
(S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol esylate salt

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 4 h / -40 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 40 °C

3: hydrogen / isopropyl alcohol; water; dimethyl sulfoxide / 18 h / 40 °C / 22496.5 Torr

4: ethanol / Reflux

With hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;