2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester
CAS No.:1621689-17-5
Molecular Formula:C₂₉H₂₆N₆O₄
Molecular Weight:522.563
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

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Chemical Property of 2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

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Technology Process of 2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

There total 4 articles about 2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1621689-01-7
lithium 3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoate

: 509093-64-5
2,2-dimethylpropionic acid 2-amino-1H-benzoimidazol-5-yl ester

: 1621689-17-5
2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1621689-17-5
2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 12 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-ol; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 1621689-02-8
3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoic acid methyl ester

: 1621689-17-5
2,2-dimethylpropionic acid 2-[3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoylamino]-1H-benzoimidazol-5-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;