(S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate
CAS No.:1254319-21-5
Molecular Formula:C₂₆H₂₉F₂N₃O₄
Molecular Weight:485.531
Hs Code.:

Synonyms:(S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

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Chemical Property of (S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

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Technology Process of (S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

There total 1 articles about (S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254319-20-4
(S)-tert-butyl 4-(1-amino-3-(3',4'-difluorobiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

: 1254319-21-5
(S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Guidance literature:: With Burgess Reagent; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1254319-21-5
(S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

: 76-05-1
trifluoroacetic acid

: (S)-4-amino-N-(1-cyano-2-(3,4-difluorobiphenyl-4-yl)ethyl)tetrahydro-2H-pyran-4-carboxamide trifluoroacetic acid salt

Guidance literature:: (S)-tert-butyl 4-(1-cyano-2-(3',4'-difluorobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate; With formic acid; at 20 ℃; for 3h;

trifluoroacetic acid;