3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

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Chemical Name:3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid
CAS No.:1445878-70-5
Molecular Formula:C₃₁H₃₃N₅O₆S
Molecular Weight:603.699
Hs Code.:

Synonyms:3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

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Chemical Property of 3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

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Technology Process of 3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

There total 8 articles about 3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445879-93-5
3-{[7-bromo-3-(1-pyrrolidinylsulfonyl)-4-quinolinyl]amino}-5-cyclopentylbenzoic acid

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445878-70-5
3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 125 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445878-70-5
3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 20 °C

4: acetic acid / 2 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 125 °C / Microwave irradiation

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1374868-46-8
3-amino-5-cyclopentylbenzoic acid

: 1445878-70-5
3-cyclopentyl-5-((7-(2,4-dimethoxypyrimidin-5-yl)-3-(pyrrolidin-1-ylsulfonyl)quinolin-4-yl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.42 h / 125 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;