methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

Base Information

Chemical Name:methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate
CAS No.:1391763-20-4
Molecular Formula:C₂₄H₂₀N₂O₃
Molecular Weight:384.434
Hs Code.:

Synonyms:methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

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Chemical Property of methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

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Technology Process of methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

There total 3 articles about methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 22187-13-9
1,4-dihydro-1,4-epoxyanthracene

: 82417-84-3
methyl 2-chloro-2-(4-methylphenyl-hydrazono)acetate

: 1391763-20-4
methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

Guidance literature:: With triethylamine; In chloroform; at 50 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ejoc.201300110

Reference yield:

: C₁₉H₁₈F₃IO₄SSi

: 1391763-20-4
methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride; diisopropylamine / tetrahydrofuran / 20 °C

2: triethylamine / chloroform / 6 h / 50 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; In tetrahydrofuran; chloroform;
DOI:10.1002/ejoc.201300110

Reference yield:

: 442912-20-1
1,3-dihydro-1,1,3,3-tetramethylnaphth[2,3-c][1,2,5]oxadisilole

: 1391763-20-4
methyl 1-(4-methylphenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / dichloromethane / 0 - 20 °C

2: tetrabutyl ammonium fluoride; diisopropylamine / tetrahydrofuran / 20 °C

3: triethylamine / chloroform / 6 h / 50 °C / Inert atmosphere

With trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1002/ejoc.201300110